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💤 What is Narcolepsy
Narcolepsy is a malfunction of the brain’s sleep/wake managing system.
Its most common manifestation is Excessive Daytime Sleepiness and sleep attacks.
Signs of Narcolepsy include:
✅ Temporary paralysis on dropping off to sleep or awakening (sleep paralysis).
✅ Hallucinations – vivid images or sounds – on falling asleep or awakening (Hypnopompic and hypnagogic hallucinations ).
✅ Moments (but sometimes extended durations) of trance-like behavior where regular activities are continued “auto-pilot” (Automatic behavior).
✅ Disturbance of night-time sleep by regular waking periods, marked by accelerating heart rate, over-awareness, hot flushes, agitation, and an intense craving for sugary foods.
Treatment?
There is no remedy for narcolepsy, but the symptoms can be managed with behavioral and medical therapy.
Extreme daytime drowsiness may be treated with stimulant drugs or Modafinil.
Medications will decrease the signs but will not cut them. Likewise, available many medicines have side effects.
Fundamental lifestyle adjustments such as regulating sleep schedules and setting up daytime naps.
And avoiding “over-stimulating” circumstances might also decrease the intrusion of signs into daytime activities.
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Drug Therapy Stimulants
Drug Therapy Stimulants are essential for treating excessive daytime sleepiness and sleep attacks in narcolepsy clients.
These consist of methylphenidate (Ritalin ®), dextroamphetamine, pemoline, and Modafinil.
Doses of these medications are identified on a case-by-case basis and taken in the early morning and midday.
Other drugs, such as particular antidepressants and drugs still being tested in the United States, are likewise used to treat the primary signs of narcolepsy.
The significant adverse effects of these stimulants are;
- Irritability,
- Anxiety,
- Sped up heart rate,
- High blood pressure,
- Drug abuse,
- and Disturbances of nocturnal sleep.
Methylphenidate and dextroamphetamine are understood to trigger hypertension.
Modafinil does not carry the addiction potential that methylphenidate and dextroamphetamine do.
In reality, the most recent development in treatment is a brand-new modafinil drug called Provigil ®.
Which does not serve as a stimulant and thus does not produce side effects like anxiety and irritation.
Provigil’s therapeutic effects have been observed in the upkeep of wakefulness test research study, where clients have tripled their wakefulness.
There is no treatment for narcolepsy, excessive daytime sleepiness, unexpected sleep beginning, and cataplexy.
Proper sleep hygiene, which includes a consistent sleep schedule and avoiding shift work and alcohol, can reduce the ill impact of narcolepsy.
Clients with narcolepsy feel refreshed after a brief nap; thus, taking short set-up naps may benefit clients in combating extreme daytime drowsiness.
Is Provigil Effective for the Symptoms of ADD and ADHD?
Provigil is an intriguing drug. It keeps narcoleptics from falling asleep, and it likewise appears to help individuals with Attention Deficit Disorder (ADD).
And Attention Deficit Hyperactive Disorder (ADHD) stay focused.
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How efficient is Provigil for ADHD?
That depends entirely on which study you test, given that Provigil has revealed mixed results in studies related to ADHD treatment.
The outcomes of one research study published in July 2000 were so frustrating that the maker of the medication, Cephalon Inc, chose to pursue other indications for the drug.
In February 2001, the Journal of the American Academy of Child and Adolescent Psychiatry released a study that indicated the potential benefit of Provigil (Modafinil) as an ADHD treatment.
The manufacturer’s most current research study showed ” significant enhancement “compared to a placebo, carried out by the manufacturer to get FDA approval, which showed “significant enhancement” compared to a placebo.
Your body will be the best judge of Provigil’s worth as an ADD and ADHD treatment.
But before you go to your doctor’s office requesting a prescription, there are side effects and warnings you must be aware of.
Provigil (Modafinil) Side Effects:
- Headache,
- Blurred vision,
- Dry mouth,
- Queasiness,
- Vomiting,
- Abdominal pain,
- Irregularity or diarrhea,
- Sleep disturbances/insomnia,
- Loss of appetite/weight loss,
- Stuffy nose,
- Neck and back pain,
- Confusion,
- Stress and anxiety and agitation,
- Anxiety,
- Aggressiveness,
- Hostility,
- Unsteady moods,
- Depression,
- Decreased libido,
- ” Pins and Needles” feeling,
- Rash or itching,
- Dizziness,
- Broadening of the capillary,
- Weakness or loss of strength,
- High/increased high blood pressure,
- Alteration in outcomes of liver function tests,
- Chest discomfort,
- Increased heart rate,
- Substance abuse. Allergy.
Provigil may be routine forming and has the capacity for abuse and reliance.
It would help if you talked about the abuse and dependence potential of Provigil with your medical professional.
This drug must not be taken by anybody who has been or is currently dependent on alcohol or drugs.
Symptoms of a Provigil overdose may consist of;
- excitation,
- agitation,
- insomnia,
- sleep disturbances,
- anxiety,
- irritation,
- aggressiveness,
- confusion,
- anxiety,
- trembling,
- palpitations,
- nausea,
- and diarrhea.
Before taking Provigil, tell your physician if you have; Left ventricular hypertrophy. Chest pain. Irregular heartbeats.
History of a heart attack. High blood pressure. Unsteady angina.
History of mental illness. Kidney disease Liver illness.
Contact your physician or look for emergency medical attention if you experience any of the following significant but uncommon side effects:
An allergy (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).
Irregular heartbeats. High or low high blood pressure. Shortness of breath.
Provigil may decrease the results of birth control pills to implantable formulas such as Norplant and Depo-Provera.
Ladies need to use a 2nd, non-hormonal contraception while taking Provigil and for one month after stopping Provigil to avoid pregnancy.
Before taking Provigil, tell your doctor if you take any of the following drugs: MAO inhibitors.
Tricyclic antidepressants. Valium.
Other stimulant medications. Seizure medications. Rifadin, Rimactane.
Nizoral. Sporanox. Neoral, Sandimmune. Theophylline. Warfarin. Propranolol.
How effective is Provigil for ADHD?
About 20,000 people use Provigil off-label to deal with the signs of ADHD.
Doctors recommend drugs “off label, “indicating they recommend the medicine for a condition besides exactly what was authorized by the FDA.
Though it is legal for doctors to recommend drugs off-label, drugmakers are prohibited from marketing their medicines for off-label usage.
Provigil’s manufacturer, Cephalon Inc., has asked for FDA approval for Attendance, a reformulation utilizing Provigil’s active ingredient, Modafinil.
Cephalon will be permitted to market Modafinil for ADHD by accomplishing FDA approval for Attendance.
Attendance is anticipated to strike pharmacy shelves in early 2006.
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